MachineU > China Products > Machinery > Chemical & Pharmaceutical Machinery > Chemical Machinery & Equipment > Granulators
Pharmaceutical Roller Compactor Dry Granulation For Western Medicine
Pharmaceutical Roller Compactor Dry Granulation For Western Medicine
Specifications
Payment Terms :
T/T
Model Number :
LG
Features :
no waters and solvents
Capacity :
required by customers
Warranty :
one year
Material :
SS304, 316L
Delivery Time :
30-90 days
Supplier :
Chinese factory
Certification :
CE
Price :
USD30,000-300,000
Control system :
PLC
Brand Name :
Shengman
Applicable Industry :
pharma, chemical, food industry
feeding type :
horizontal feeding type
Parts :
famous brand
Core Selling Point :
Famous Brand Plc
MOQ :
1set
Optional device :
Micro feeder device
Place of Origin :
changzhou
Supply Ability :
1-10sets/month
Packaging Details :
exporting package
Description

Pharmaceutical Roller Compactor Dry Granulation For Western Medicine

The application of Roller Compactor (dry granulation machine) in the production of western medicine (chemical drugs, biopharmaceuticals, etc.) is very mature and extensive, and it is one of its most classic and core application fields. With the deepening of continuous manufacturing and QbD concept, the importance of roller compactor in the field of Western medicine intelligent manufacturing will be further enhanced due to its easy control of parameters and integration.
Many active ingredients (APIs) in Western medicine have the following characteristics:
Sensitive to moisture and heat: Many APIs are unstable when exposed to water or heat, and are prone to hydrolysis, oxidation, or crystal transformation.
Low dose: The API content in the prescription is very low (such as less than 1%), and it needs to be evenly mixed with a large amount of excipients. Wet granulation may cause uneven content.
Insolubility: About 70% of modern new drugs are insoluble, and wet granulation may exacerbate their dissolution problems, while dry granulation does not affect their inherent dissolution characteristics.
Compliance requirements: Strictly avoid solvent residue and comply with international regulatory guidelines such as ICH.
The Roll Compactor can perfectly solve these inherent problems of Western medicine API, so roller compactor is the preferred process and equipment for Western medicine granulation production.

Pharmaceutical Roller Compactor Dry Granulation For Western Medicine

Model LG100 LG100E LG160 LG200 LG240 LG360

Capacity

(kg/h)

 1.5-15 12-40 50-150 100-240 160-320 360-720

Rated power

(kw)

 3.47 3.53 7.24 11.37 15.94 32.55
Roller size (D*W) 100*25 100*40 160*50 200*75 240*100 360*150

For large production scale application, we provide double-supporting roller model

Model LGS200 LGS240 LGS360 LGS500

Capacity

(kg/h)

 200-400 300-640 1200-2000 1500-3000

Rated power

(kw)
Roller size (D*W)

Main application scenarios and functions of dry granulation machine
1. As a pretreatment for direct tablet pressing (most commonly used)
Scenario: When the mixture of API and excipients has poor fluidity, insufficient compressibility, or there is a risk of separation, it cannot be directly pressed into tablets.
Function: Dry Granulator is used to make granules with excellent fluidity and compressibility, while ensuring that the mixing uniformity is not disrupted. This is an effective supplement to the direct compression process.
2. Handling highly active or harmful substances
Scenario: Production of highly effective drugs such as cytotoxic drugs and hormones.
Function: The entire dry granulation process is carried out in a fully enclosed system, greatly reducing the risk of operators being exposed to hazardous dust and ensuring production safety.
3. Production of water sensitive materials
Scenario: Production of easily hydrolyzed materials (such as aspirin, certain antibiotics, proton pump inhibitors, etc.).
Function: Completely avoid the use of water or organic solvents, fundamentally eliminate the risk of hydrolysis, and ensure the chemical stability of the product.
4. Improve materials dissolution behavior (under specific circumstances)
Scenario: For certain materials, the high-pressure rolling process may result in partial microcrystallization or crystal defects, which can actually increase the specific surface area and improve the dissolution rate.
Attention: This requires further research as pressure may also cause crystal transformation or have the opposite effect.
5. Production of special dosage forms such as effervescent tablets and chewable tablets
Scenario: The acid and base sources (such as citric acid and sodium bicarbonate) in effervescent tablets must not come into contact with water.
Function: Roller compactor is the only or best choice for producing intermediate particles in this type of dosage form, ensuring that all ingredients are absolutely dry before compression.

Pharmaceutical Roller Compactor Dry Granulation For Western Medicine

Why Choose Us:
We are a leading Chinese manufacturer specializing in dry granulation equipment. With extensive experience in custom engineering solutions, we ensure that each machine meets your unique production requirements, improving efficiency and product quality.

Call-to-Action:
Contact us today to discuss your production needs and get a customized dry granulation solution!

Send your message to this supplier
Send Now

Pharmaceutical Roller Compactor Dry Granulation For Western Medicine

Ask Latest Price
Watch Video
Product Detail
Payment Terms :
T/T
Model Number :
LG
Features :
no waters and solvents
Capacity :
required by customers
Warranty :
one year
Material :
SS304, 316L
Contact Supplier
video
Pharmaceutical Roller Compactor Dry Granulation For Western Medicine

Jiangsu Shengman Drying Equipment Engineering Co., Ltd

Verified Supplier
6 Years
jiangsu, changzhou
Since 2011
Business Type :
Manufacturer
Main Products :
Spray Drying Machine, Hollow Paddle Dryer, Drum Drying Machine
Total Annual :
10000000-20000000
Employee Number :
50~100
Certification Level :
Verified Supplier
Discover similar products
View More

Find Similar Products By Category:

Supplier Homepage Products Dry Granulator
MachineU China Products Machinery Chemical & Pharmaceutical Machinery Chemical Machinery & Equipment Granulators
Contact Supplier
Submit Requirement