Vitamin B12, also known as cobalamin, is a polycyclic compound containing trivalent cobalt. Adverse effects include promoting the growth of malignant tumors and causing rashes, itching, diarrhea, and asthma. Four reduced pyrrole rings are linked together to form a corrin macrocycle (similar to porphyrin), making it the only vitamin to contain a metal element.
Vitamin B12 is a red crystalline powder that is odorless and tasteless. It is soluble in water, poorly soluble in ethanol. It is most stable in weakly acidic conditions with a pH of 4.5 to 5.0. It decomposes in strong acids (pH < 2) or alkaline solutions and can be damaged to some extent by heat. Higher plants and animals cannot produce vitamin B12; all vitamin B12 found in nature is synthesized by microorganisms.
Vitamin B12 is the only vitamin that requires a secretion from gastric parietal cells (intrinsic factor) for absorption. It is involved in the production of red blood cells in the bone marrow, preventing pernicious anemia, and protecting against brain nerve damage.
1. Maintaining a Healthy Nervous System
Protecting Nerve Cells: Vitamin B12 is involved in the synthesis of myelin, a fatty sheath that surrounds nerve fibers, similar to the insulation of an electrical wire. Myelin ensures the rapid and accurate transmission of nerve signals. A B12 deficiency can damage the myelin sheath, causing a "short circuit" in nerve signaling and leading to various neurological symptoms.
Preventing Neuropathy: Adequate B12 levels can prevent numbness, tingling, or burning sensations in the hands and feet, memory loss, difficulty concentrating, and even difficulty walking.
2. Promoting Red Blood Cell Production and Preventing Pernicious Anemia
Participating in DNA Synthesis: B12 is required for cell division and DNA synthesis, making it crucial for rapidly dividing cells, such as hematopoietic cells.
Preventing Megaloblastic Anemia: B12 deficiency can cause red blood cells to fail to mature properly, resulting in enlarged but incomplete red blood cells (called megaloblasts). This leads to decreased oxygen transport capacity and anemia symptoms such as fatigue, paleness, and shortness of breath. This type of anemia is often accompanied by neurological symptoms.
3. Participates in energy metabolism and relieves fatigue.
Helping with energy conversion: B12 acts as a coenzyme, participating in the metabolism of carbohydrates, fats, and proteins in the body, helping to convert them into usable energy (ATP). This is why B12 deficiency can lead to extreme fatigue and weakness.
Although it doesn't directly provide energy, a deficiency can severely impair energy production.
4. Supports DNA synthesis and cell division.
As a crucial coenzyme, B12 is essential for DNA replication and division in all cells, especially those with rapid turnover rates, such as intestinal cells, skin cells, and blood cells.
Pharmaceutical Applications:
Nutraceutical Applications:
Item | Specification | Results |
Assay | 98.5%-100.5% | 99.6% |
Odor | Characteristic | conforms |
Appearance | Dark Red Crystalline Powder | conforms |
Taste | Characteristic | conforms |
Particle Size | NLT 100% Through 80 mesh | conforms |
Loss on Drying | <12.0% | 2.2% |
Heavy metals | ||
Total Heavy Metals | ≤10ppm | conforms |
Arsenic | ≤3ppm | conforms |
Lead | ≤3ppm | conforms |
Related substances | ||
Total Impurities | ≤3.0% | 1.7% |
Single impurities | ≤1.0% | <1.0% |
Microbiological Tests | ||
Total Plate Count | ≤1000cfu/g | 15cfu/g |
Total Yeast & Mold | ≤100cfu/g | <10cfu/g |
E.Coli | Negative | Negative |
Salmonella | Negative | Negative |
Our packing method is 1KG/Aluminium bags, 25kg/drum
For some products that require special packaging during transportation, we will carry out more delicate packaging. For example, retinal needs to be stored at -20 °C, so we choose cold chain transportation during transportation; deoxyarbutin will change color during transportation, so we will Vacuum packing of deoxyarbutin