Nesiritide is a recombinant form of human B-type natriuretic peptide (BNP), a 32-amino acid peptide hormone naturally produced by the ventricular myocardium[1][6]. It is a potent natriuretic peptide receptor agonist, manufactured via recombinant DNA technology from E. coli, with the same amino acid sequence as endogenous human BNP[9].

Our Nesiritide Peptide Powder is supplied as a white to off-white lyophilized powder with ultra-high purity, good water solubility, excellent biological activity. It is produced in a GMP-compliant cleanroom environment, undergoing strict quality control and batch testing to ensure consistency and reliability, fully meeting the requirements of pharmaceutical R&D, scientific research, and industrial manufacturing[8][9].

• Acts as a potent agonist of natriuretic peptide receptors (NPRs), specifically binding to particulate guanylate cyclase receptors on vascular smooth muscle and endothelial cells[1][6][9].
• Triggers guanylate cyclase-dependent signal transduction, increasing intracellular concentrations of cyclic guanosine monophosphate (cGMP), which serves as a second messenger to induce smooth muscle cell relaxation[1][9].
• Causes arterial and venous dilatation, leading to dose-dependent reductions in pulmonary capillary wedge pressure (PCWP) and systemic arterial pressure in patients with heart failure[5][9].
• Does not affect cardiac contractility or cardiac electrophysiology (e.g., atrial and ventricular effective refractory times), ensuring safety in cardiovascular applications[9].
• Exerts natriuretic and diuretic effects, helping to reduce intravascular volume and alleviate symptoms of heart failure[5][6].

• Pharmaceutical API: Used in the R&D and production of injectable preparations for the treatment of acutely decompensated congestive heart failure (ADHF), to reduce pulmonary capillary wedge pressure and improve dyspnea symptoms[5][6].
• Research & Development: Applied in preclinical pharmacology, toxicology, and formulation optimization studies related to heart failure, cardiovascular diseases, and natriuretic peptide receptor signaling pathways[6][9].
• Scientific Research: Suitable for laboratory studies on ventricular myocardium function, heart failure pathogenesis, and the development of novel anti-heart failure therapeutics[1][6].
• Biomedical Research: Used in studies on vascular dilatation mechanisms, natriuretic peptide biology, and cardio-renal syndrome[6].

• Ultra-High Purity: HPLC ≥98.0%, strict control of impurities, ensuring high biological activity and safety for pharmaceutical R&D and formulation[8][9].
• Authentic Recombinant Peptide: Produced via advanced recombinant DNA technology, consistent with the amino acid sequence of endogenous human BNP[9].
• Stable Quality: Strict production process control and comprehensive analytical testing (COA, HPLC, MS, NMR) provided for each batch, ensuring batch-to-batch consistency[7][8].
• Professional Manufacturing: Produced in a GMP-compliant cleanroom with strict contamination control, meeting international pharmaceutical and research standards[8][9].
• Excel-Exportable Specifications: The key specifications table can be directly copied to Excel, facilitating your product management and customer communication.
• Complete Documentation: Full technical dossiers, including COA, MSDS, stability data, and analytical reports, available upon request to support global regulatory filings[8][9].

• Storage: Store at ≤ -20°C, protected from light, heat, and moisture; keep desiccated in a dark place to avoid degradation[2][7]. Shelf life is 3 years under proper storage conditions[7].
• Transport: Transport with dry ice or professional cold-chain packaging to maintain low-temperature stability; avoid long-term exposure to ambient temperature[8].
• Reconstituted Solution: Use within 24 hours after reconstitution; reconstituted vials may be stored at 2°C to 25°C for up to 24 hours[3].
• Avoid repeated freeze-thaw cycles, as this may affect peptide activity and biological potency[7][9].
• Handling: Wear protective gloves, clothing, and goggles; operate in a well-ventilated area to avoid inhalation and skin/eye contact[8].

• For research and industrial manufacturing use only.
• Not for direct human or animal administration; intended for pharmaceutical formulation, laboratory research, or R&D use only[8][9].
• Strictly comply with local laws and regulations regarding peptide APIs, pharmaceutical raw materials, and controlled substances; Nesiritide is a prescription-only in most jurisdictions[5][6].
• Full MSDS (Material Safety Data Sheet) with detailed safety information, including adverse effects (e.g., hypotension, tachycardia) and handling precautions, is provided with each order[5][8].

• Packing: 0.1g, 0.5g, 1g, 5g, 10g, 100g sealed lyophilized vials or aluminum foil bags; customizable packaging available based on order quantity[2][8].
• MOQ: Flexible, supporting small-batch R&D orders and large-scale bulk orders.
• Lead Time: In-stock items shipped within 2–3 working days; custom orders negotiated based on quantity.
• Shipping: Cold-chain transport via DHL, FedEx, UPS, or international air/sea freight, with full tracking provided to ensure safe delivery[8].