High Purity Capmatinib intermediates CAS 749927-69-3 and CAS 69249-22-5 and CAS 1197377-31-3
| Product Name | Capmatinib intermediates |
| Intermediate CAS | CAS 749927-69-3 and CAS 69249-22-5 and CAS 1197377-31-3 |
| Appearance | A White to off-white or tan solid powder |
| Molecular formula | C21H20FN3O6S |
| Molecular Weight | 461.46 |
| Assay | 99% |
| Shelf Life | 24 months when properly stored |
| Storage | Keep in a cool, dry, dark location |
Acalabrutinib, also known as ACP-196, is an orally available Bruton tyrosine kinase (BTK) inhibitor with potential antitumor activity.When applied, ACP-196 inhibits BTK activity and blocks activation of the B cell antigen receptor (BCR) signaling pathway.This prevents B cell activation and BTK-mediated activation of downstream survival pathways.
This leads to inhibition of the growth of malignant B cells that overexpress BTK.BTK is a member of the Src associated BTK/TEC cytoplasmic tyrosine kinase family and is overexpressed in B-cell malignancies.It plays an important role in B lymphocyte development, activation, signaling, proliferation, and survival.
Supply Acalabrutinib ACP-196 Powder CAS 1420477-60-6 Acalabrutinib
