GMP Standard Vonoprazan fumarate( TAK-438 ) intermediates CAS 881677-11-8 and 16133-25-8 and 881674-56-2 and 1240948-72-4 and 1240948-77-9
| Product Name | Vonoprazan fumarate TAK438 |
| Intermediate CAS | CAS 881677-11-8 and 16133-25-8 and 881674-56-2 and 1240948-72-4 and 1240948-77-9 |
| Appearance | A White to off-white or tan solid powder |
| Molecular formula | C21H20FN3O6S |
| Molecular Weight | 461.46 |
| Assay | 99% |
| Shelf Life | 24 months when properly stored |
| Storage | Keep in a cool, dry, dark location |
Vonoprazan can be used for the treatment of gastroduodenal ulcer (including some -induced peptic ulcers) and reflux esophagitis, and can be combined with antibiotics for the eradication of Helicobacter pylori.
Vonoprazan fumarate shows strong and sustainable acid secretion inhibitory effects as well as demonstrate efficacy in early termination by inhibiting the binding of potassium ion (K+) to H+, K+-ATPase (proton pump) in the final step of gastric acid secretion in gastric parietal cell.
