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(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research
(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research
(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research
(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research
Specifications
Model Number :
CAS 877397-65-4
Molecular Formula :
C₈H₇Cl₂FO
Supply Ability :
1T
Payment Terms :
T/T
Density :
1.4 g/cm³
Delivery Time :
5-7 work days
Place of Origin :
China
Molecular Weight :
209.045
Price :
5240-5250USD
Packaging Details :
drum
Available Purity :
98%, 99%
Brand Name :
Xuanming
CAS Number :
877397-65-4
MOQ :
1 kg
Appearance :
Off-white crystalline powder
Description
(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research
Product Introduction

(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research

Core Specification Table(8 items)
Index Data
CAS Number 877397-65-4
Molecular Formula C₈H₇Cl₂FO
Molecular Weight 209.045
Appearance Off-white crystalline powder
Melting Range 42–46 ℃
Boiling Point 261.3 ℃ (760 mmHg)
Available Purity 98%, 99%
Density 1.4 g/cm³

Core Product Properties

1. Pure S Chiral Configuration

This compound only contains S enantiomer without racemic mixtures. Optical rotation test data keeps consistent across different batches, and chiral structure will not convert to R configuration under sealed dark storage.

2. Uniform Crystal Morphology

Fine crystalline particles without caking or foreign impurities, dissolves evenly in common organic solvents to reduce experimental reaction errors.

3. Selective Solubility Trait

Slightly soluble in methanol, ethanol and DMSO; insoluble in water, alkane and solvents, matching solvent system for pharmaceutical chiral synthesis.

4. Reliable Thermal Stability

No racemization or molecular cracking below 100 ℃. Thermal decomposition only occurs when temperature exceeds 260 ℃, releasing halogen-containing by-products.

5. Active Hydroxyl Functionality

The chiral hydroxyl group supports esterification, substitution and cross-coupling reactions, acting as key unit to construct crizotinib molecular skeleton.

6. Strict Impurity Control

Moisture, single unknown impurity and halogen residue are limited within inspection thresholds for intermediates, fit for lab test and pilot scale-up preparation.

7. Anti-Oxidation Storage Stability

Chlorine and fluorine substitution strengthens molecular stability. Shelf life reaches 2 years under airtight cool environment with no obvious quality decline.

8. Stable Batch Consistency

Fixed element proportion and molecular composition for every batch, delivering steady conversion rate in downstream synthesis steps.

Application Scope

  1. Essential synthetic precursor of crizotinib for non-small cell lung cancer targeted therapy
  2. Raw material for asymmetric catalysis and chiral compound structural modification lab tests
  3. Intermediate for developing new small-molecule kinase inhibitor

Storage & Handling Guidance

  1. Short-term storage: 2–8 ℃, fully sealed and shaded environment
  2. Long-term storage: -20 ℃ airtight container to extend service cycle
  3. Isolate from strong oxidants, high-temperature heat sources and ultraviolet radiation
  4. Reduce frequent opening of packaging to avoid moisture absorption and light-induced racemization
Physical Properties

Solid chiral aromatic alcohol under ambient temperature. Slightly soluble in methanol, insoluble in water. Crystalline structure maintains stable optical rotation under sealed storage.

Chemical Properties

No spontaneous decomposition at room temperature. Hydroxyl group supports esterification reaction. Single S configuration avoids racemic impurities during downstream synthesis. Thermal decomposition releases hydrogen halide under high heat.

Application Scope

Chiral building block for compound preparation, laboratory asymmetric synthesis research, fine chemical intermediate production.

Storage Guidance

Seal container tightly, place inside low temperature dry space, isolate from strong oxidants and direct sunlight exposure.


(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research

(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research

(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research

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(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research

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Product Detail
Model Number :
CAS 877397-65-4
Molecular Formula :
C₈H₇Cl₂FO
Supply Ability :
1T
Payment Terms :
T/T
Density :
1.4 g/cm³
Delivery Time :
5-7 work days
Contact Supplier
(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research
(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research

Changzhou Xuanming Chemical Industry Co., Ltd

Verified Supplier
1 Years
jiangsu, changzhou
Business Type :
Manufacturer
Main Products :
API, Custom Peptide, Custom Chemicals
Total Annual :
20000000-30000000
Employee Number :
>10
Certification Level :
Verified Supplier
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