GMP Negative Pressure Weighing Booth | H14 HEPA Filtration | Dust Containment System

Engineered for precise material handling in pharmaceutical production, this weighing booth prevents cross-contamination while maintaining GMP-compliant environmental conditions. Ideal for potent compound weighing and dispensing operations.

Product Features

1. Advanced Containment Technology

• Negative pressure design: Maintains -15Pa to -30Pa gradient to prevent dust escape

• Triple-stage filtration: Combines G4→F8→H14 filters for 99.995% particle retention

2. Precision Process Control

• Dual 1.5KW fans: Ensure stable airflow (0.45±0.1m/s) during material transfers

• Real-time monitoring: Touchscreen displays differential pressure, wind speed, and filter status

3. GMP-Compliant Construction

• 304 stainless steel: Resists disinfectants and prevents particle shedding

• Seamless welds: Eliminate contamination traps per EU GMP Annex 1

4. Operational Safety

• Automatic alarms: Trigger for pressure deviations or filter saturation

• Emergency stop: Instantly halts operations if containment is compromised

Application Scenarios

1. Potent Compound Handling

• Contains cytotoxic dust during oncology drug dispensing (USP <800> compliant)

2. API Weighing

• Maintains ISO 8 conditions for active pharmaceutical ingredient measurement

3. Excipient Preparation

• Prevents cross-contamination in multi-product facilities

4. Sterile Formulation

• Protects sterile cores during tablet compression line feeding

5. R&D Laboratories

• Enables safe handling of experimental compounds in early development

Technical Validation

• Filter Efficiency: EN 1822-5:2009 tested at MPPS (0.12-0.25μm)

• Pressure Control: Validated per ISO 14644-3 Annex B4

• Material Compliance: ASTM A240 304 stainless steel, Ra ≤0.5μm

FQAs

Q1: How does the negative pressure system prevent hazardous powder exposure?
The booth maintains -15Pa to -30Pa pressure gradient with dual 1.5KW fans, creating inward airflow that contains 99.9% of particles ≥5μm. This exceeds OSHA 29 CFR 1910.134 requirements for hazardous drug handling.

Q2: What makes your H14 filter more effective than standard HEPA?
Our MRJH H14 filters are MPPS-tested at 0.12μm (vs standard 0.3μm), capturing 99.995% of particles - critical for potent compounds like cytotoxics. Includes DOP test ports for routine validation.

Q3: Can the system handle continuous weighing of multiple APIs?
Yes, the 304 stainless steel interior and flow equalization membrane prevent cross-contamination during product changeovers. Touchscreen logs each session for 21 CFR Part 11 compliance.