Introduction
p16/Ki-67 Dual Staining is an important marker for cervical cancer screening and diagnosis.
The p16/Ki-67 Dual Staining technology is a new detection method joint recommended by CAP and ASCCP, also recommended by Bethesda Version 2015.
Test principle
- p16 causes cell cycle arrest
- Ki-67 marks cell proliferation
- Simultaneous expression suggests a cell cycle disorder, a "carcinoma."
Advantage
- Dual-stainin, specificity is better than HR-HPV
- Positive result of dual staining indicates Cervical cells are cancerous
Higher sensitivity
- Bypassed with higher sensitivity and specificity